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Association of catechol‐ O ‐methyl transferase (COMT) gene −287A/G polymorphism with susceptibility to obsessive–compulsive disorder in Chinese Han population
Author(s) -
Liu Shiguo,
Liu Yanhui,
Wang Haiping,
Zhou Ruiling,
Zong Jinbao,
Li Changgui,
Zhang Xinhua,
Ma Xu
Publication year - 2011
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31173
Subject(s) - obsessive compulsive , polymorphism (computer science) , genetics , han chinese , catechol o methyl transferase , chinese population , psychology , gene , allele , biology , genotype , psychiatry , single nucleotide polymorphism
Several studies suggested a genetic component in the etiology of obsessive–compulsive disorder (OCD). COMT involves in the degradation of dopamine and norepinephrin. As another functional SNP locus, COMT −287A/G polymorphism showed an effect on enzyme activity, suggesting that it may influence brain dopamine levels. To identify association of COMT −287A/G polymorphism with susceptibility to OCD in Chinese Han population. We evaluate the genetic contribution of the COMT −287A/G polymorphism in 200 OCD patients and 403 OCD‐free control of Chinese Han population by PCR‐RFLP. In addition, we investigate whether COMT −287A/G polymorphism is associated with one or more of these symptom dimensions or other characteristics such as sex, age of onset, and tic‐relatedness and evaluate the association of the factorial structure of OCD symptoms from the Y‐BOCS checklist with the COMT −287A/G polymorphism. A statistical difference was found in the genotypic frequencies of COMT −287A/G between the OCD and control groups ( χ 2 = 13.99, DF = 2, P = 0.00091) and in the genotypic frequencies of GG genotype versus AA and AG genotypes of COMT −287 ( χ 2 = 13.49, DF = 1, P = 0.00024, OR = 3.43, 95% CI = 1.78–6.62). There was a trend for an association in the genotypic distributions of COMT −287A/G polymorphism of males ( χ 2 = 27.81; DF = 2; P < 0.001) and females ( χ 2 = 7.31; DF = 2; P = 0.026) between the OCD patients and the controls. Using principal component analysis, we derived 5 factors from 12 main contents of OCD symptoms from the Y‐BOCS checklist and found no association with COMT −287A/G polymorphism. Our study supports the involvement of the COMT −287A/G polymorphism in the genetic susceptibility to OCD in Chinese Han population. © 2011 Wiley‐Liss, Inc.