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Increased symptoms of attention deficit hyperactivity disorder and major depressive disorder symptoms in nail‐patella syndrome: Potential association with LMX1B loss‐of‐function
Author(s) -
LópezArvizu Carmen,
Sparrow Elizabeth P.,
Strube Michael J,
Slavin Chris,
DeOleo Caroline,
James Justin,
HooverFong Julie,
McIntosh Iain,
Tierney Elaine
Publication year - 2011
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31138
Subject(s) - attention deficit hyperactivity disorder , odds ratio , major depressive disorder , dopaminergic , psychology , medicine , clinical psychology , dopamine , mood
Nail‐Patella syndrome (NPS) is an autosomal dominant disorder that is the result of heterozygous loss‐of‐function mutations in LMX1B , coding for a LIM homeobox (LIM‐HD) transcription factor. Analyses of lmx1b mutant mice have revealed the role of Lmx1b in the development of mesencephalic dopaminergic neurons and the serotonergic system; these areas have been linked with symptoms of attention deficit hyperactivity disorder (ADHD) and major depressive disorder (MDD). Fifty adults (38 females, 12 males) with NPS completed the Conners' Adult ADHD Rating Scales—Self‐report: Long Version ( CAARS ) and Beck Depression Inventory‐II ( BDI‐II ). The objective was to describe the neurobehavioral phenotype of these subjects and examine possible relationships between neurobehavioral symptoms and NPS. Elevated levels of DSM‐IV‐TR ADHD Inattentive symptoms were reported on the CAARS by 22% of the NPS sample. The BDI‐II Total score was elevated for 40% of the NPS sample. There was a significant increase in the odds of an elevated BDI‐II Total score when any of the three CAARS scales were elevated (odds ratios ranging from 11.455 to 15.615). The CAARS and BDI‐II did not significantly differ with gender, age, or education level. There was no significant association between genetic mutation‐predicted protein status and elevations on CAARS or BDI‐II . Individuals with NPS reported co‐occurring symptoms of ADHD and MDD, with higher levels of co‐occurrence than reported in the literature for the general population. The co‐occurrence of these symptoms may be related to mesencephalic dopaminergic neurologic pathway abnormalities that are a consequence of LMX1B loss of function. © 2010 Wiley‐Liss, Inc.