Premium
Mapping for dyslexia and related cognitive trait loci provides strong evidence for further risk genes on chromosome 6p21
Author(s) -
König Inke R.,
Schumacher Johannes,
Hoffmann Per,
Kleensang André,
Ludwig Kerstin U.,
Grimm Tiemo,
Neuhoff Nina,
Preis Maike,
Roeske Darina,
Warnke Andreas,
Propping Peter,
Remschmidt Helmut,
Nöthen Markus M.,
Ziegler Andreas,
MüllerMyhsok Bertram,
SchulteKörne Gerd
Publication year - 2011
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31135
Subject(s) - dyslexia , genetics , cognition , quantitative trait locus , trait , biology , candidate gene , proband , population , locus (genetics) , psychology , cognitive psychology , gene , medicine , computer science , reading (process) , psychiatry , law , mutation , programming language , environmental health , political science
In a genome‐wide linkage scan, we aimed at mapping risk loci for dyslexia in the German population. Our sample comprised 1,030 individuals from 246 dyslexia families which were recruited through a single‐proband sib pair study design and a detailed assessment of dyslexia and related cognitive traits. We found evidence for a major dyslexia locus on chromosome 6p21. The cognitive trait rapid naming (objects/colors) produced a genome‐wide significant LOD score of 5.87 ( P = 1.00 × 10 −7 ) and the implicated 6p‐risk region spans around 10 Mb. Although our finding maps close to DYX2, where the dyslexia candidate genes DCDC2 and KIAA0319 have already been identified, our data point to the presence of an additional risk gene in this region and are highlighting the impact of 6p21 in dyslexia and related cognitive traits. © 2010 Wiley‐Liss, Inc.