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Variation at the GABA A receptor gene, Rho 1 ( GABRR1 ) associated with susceptibility to bipolar schizoaffective disorder
Author(s) -
Green Elaine K.,
Grozeva Detelina,
Moskvina Valentina,
Hamshere Marian L.,
Jones Ian R.,
Jones Lisa,
Forty Liz,
Caesar Sian,
GordonSmith Katherine,
Fraser Christine,
Russell Ellie,
St Clair David,
Young Allan H.,
Ferrier Nicol,
Farmer Anne,
McGuffin Peter,
Holmans Peter A.,
Owen Michael J.,
O'Donovan Michael C.,
Craddock Nick
Publication year - 2010
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31108
Subject(s) - schizoaffective disorder , bipolar disorder , schizophrenia (object oriented programming) , psychosis , gene , genetics , psychology , biology , psychiatry , cognition
We have previously reported evidence that variation at GABA A receptor genes is associated with susceptibility to bipolar disorder with schizophrenia‐like psychotic features (Research Diagnostic Criteria (RDC) schizoaffective disorder, bipolar type) with gene‐wide significance at GABRB1 , GABRA4 , GABRB3 , GABRA5 , and GABRR3. Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene‐wide P = 0.0058; experiment‐wide corrected significance P = 0.052). © 2010 Wiley‐Liss, Inc.