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An investigation of candidate regions for association with bipolar disorder
Author(s) -
Knight Jo,
Rochberg Nanette S.,
Saccone Scott F.,
Nurnberger John I.,
Rice John P.
Publication year - 2010
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31100
Subject(s) - single nucleotide polymorphism , candidate gene , snp , genetics , genetic association , bipolar disorder , biology , association (psychology) , gene , genotype , psychology , endocrinology , lithium (medication) , psychotherapist
We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P ‐values of 2 × 10 −5 ). Both P ‐values are in the top 5% of the distribution derived from null simulations ( P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. © 2010 Wiley‐Liss, Inc.