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Genome‐scan for bipolar disorder with sib‐pair families in the Sardinian population: A new susceptibility locus on chromosome 1p22–p21?
Author(s) -
Del Zompo Maria,
Severino Giovanni,
Ardau Raffaella,
Chillotti Caterina,
Piccardi Mariapaola,
Dib Colette,
Muzard Gaëlle,
Soubigou Stéphane,
Derock Murielle,
Fournel Raphaël,
Vaubien Yves,
Roche Sandrine,
BowenSquires Laurent,
Génin Emmanuelle,
Cousin Emmanuelle,
Deleuze JeanFrançois,
Biguet Nicole Faucon,
Mallet Jacques,
Meloni Rolando
Publication year - 2010
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31092
Subject(s) - microsatellite , locus (genetics) , genetics , genome scan , biology , genetic linkage , population , bipolar disorder , genetic predisposition , allele , medicine , gene , cognition , environmental health , neuroscience
The discovery of the genetic factors implicated in the predisposition to complex diseases may greatly profit from genetic studies in isolated populations. In this perspective, we performed a genome‐wide scan using 507 microsatellite markers, with an average interval size of 7.6 cM, on a sample of 88 nuclear families with at least two affected sibs with bipolar disorder recruited in the Sardinian population. An initial analysis yielded non‐parametric linkage exceeding 3.4 with P ‐values <0.0003 at two adjacent markers, D1S206 and D1S435 in the 1p22–p21 chromosomal region. Moreover, positive linkage ranging between 2.0 and 3.0 was obtained for other loci in several cases in regions that have already been linked to predisposition to bipolar disorder, such as 5p15.33, 8q24.13, and 11q14.3. A subsequent analysis of the 1p22–p21 region using the same set of families and a dense panel of 20 new microsatellite markers, spaced at 1.2 cM on average, reinforced the finding of suggestive linkage for this region. Interestingly, NPL values above 2.1 and P ‐values <0.02 were obtained for a cluster of 10 markers comprising D1S435. Thus, this study suggests that the 1p22–p21 region may contain a new locus participating to the genetic susceptibility to bipolar disorder and reproduces positive linkage for several other loci already implicated in this pathology. Since the Sardinian population presents a peculiar genetic homogeneity, these results may pave the way to further studies for replication in this population contributing to the rapid discovery of the genetic factors predisposing to bipolar disorder. © 2010 Wiley‐Liss, Inc.