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No association of the serotonin transporter polymorphisms 5‐HTTLPR and RS25531 with schizophrenia or neurocognition
Author(s) -
Konneker Thomas I.,
Crowley James J.,
Quackenbush Corey R.,
Keefe Richard S.E.,
Perkins Diana O.,
Stroup T. Scott,
Lieberman Jeffrey A.,
van den Oord Edwin,
Sullivan Patrick F.
Publication year - 2010
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31077
Subject(s) - 5 httlpr , neurocognitive , serotonin transporter , schizophrenia (object oriented programming) , medicine , odds ratio , psychiatry , oncology , polymorphism (computer science) , genotype , psychology , biology , genetics , cognition , serotonin , gene , receptor
A promoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5‐HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects. In a logistic regression with case/control status as dependent variable and 7 ancestry‐informative principal components as covariates, the effect of 5‐HTTLPR/rs25531 composite genotype was not significant (odds ratio = 1.008, 95% CI 0.868–1.172, P = 0.91). In cases only, 5‐HTTLPR/rs25531 was not associated with neurocognition (summary neurocognitive index P = 0.21, working memory P = 0.32) or symptomatology (PANSS positive P = 0.67 and negative symptoms P = 0.46). We were unable to identify association of the triallelic 5‐HTTLPR with schizophrenia, neurocognition, or core psychotic symptoms even at levels of significance unadjusted for multiple comparisons. © 2010 Wiley‐Liss, Inc.
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