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Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?
Author(s) -
Brandys Marek K.,
van Elburg Annemarie A.,
Loos Ruth J.F.,
Bauer Florianne,
Hendriks Judith,
van der Schouw Yvonne T.,
Adan Roger A.H.
Publication year - 2010
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31026
Subject(s) - single nucleotide polymorphism , body mass index , genome wide association study , allele , anorexia nervosa , genetic association , genetics , logistic regression , population , biology , medicine , genotype , eating disorders , psychiatry , gene , environmental health
The influence of body mass index (BMI) on susceptibility to anorexia nervosa (AN) is not clear. Recently published genome‐wide association (GWA) studies of the general population identified several variants influencing BMI. We genotyped these variants in an AN sample to test for association and to investigate a combined effect of BMI‐increasing alleles (as determined in the original GWA studies) on the risk of developing the disease. Individual single nucleotide polymorphisms (SNPs) were tested for association with AN in a sample of 267 AN patients and 1,636 population controls. A logistic regression for the combined effect of BMI‐increasing alleles included 225 cases and 1,351 controls. We found no significant association between individual SNPs and AN. The analysis of a combined effect of BMI‐increasing alleles showed absence of association with the investigated condition. The percentages of BMI‐increasing alleles were equal between cases and controls. This study found no evidence that genetic variants regulating BMI in the general population are significantly associated with susceptibility to AN. © 2009 Wiley‐Liss, Inc.