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Association analyses between brain‐expressed fatty‐acid binding protein ( FABP ) genes and schizophrenia and bipolar disorder
Author(s) -
Iwayama Yoshimi,
Hattori Eiji,
Maekawa Motoko,
Yamada Kazuo,
Toyota Tomoko,
Ohnishi Tetsuo,
Iwata Yasuhide,
Tsuchiya Kenji J.,
Sugihara Genichi,
Kikuchi Mitsuru,
Hashimoto Kenji,
Iyo Masaomi,
Inada Toshiya,
Kunugi Hiroshi,
Ozaki Norio,
Iwata Nakao,
Nanko Shinichiro,
Iwamoto Kazuya,
Okazaki Yuji,
Kato Tadafumi,
Yoshikawa Takeo
Publication year - 2010
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.31004
Subject(s) - bipolar disorder , prepulse inhibition , schizophrenia (object oriented programming) , fatty acid binding protein , single nucleotide polymorphism , genetic association , genetics , biology , gene , disc1 , medicine , genotype , psychiatry , mood
Deficits in prepulse inhibition (PPI) are a biological marker for psychiatric illnesses such as schizophrenia and bipolar disorder. To unravel PPI‐controlling mechanisms, we previously performed quantitative trait loci (QTL) analysis in mice, and identified Fabp7 , that encodes a brain‐type fatty acid binding protein (Fabp), as a causative gene. In that study, human FABP7 showed genetic association with schizophrenia. FABPs constitute a gene family, of which members FABP5 and FABP3 are also expressed in the brain. These FABP proteins are molecular chaperons for polyunsaturated fatty acids (PUFAs) such as arachidonic and docosahexaenoic acids. Additionally, the involvement of PUFAs has been documented in the pathophysiology of schizophrenia and mood disorders. Therefore in this study, we examined the genetic roles of FABP5 and 3 in schizophrenia (N = 1,900 in combination with controls) and FABP7 , 5 , and 3 in bipolar disorder (N = 1,762 in the case–control set). Three single nucleotide polymorphisms (SNPs) from FABP7 showed nominal association with bipolar disorder, and haplotypes of the same gene showed empirical associations with bipolar disorder even after correction of multiple testing. We could not perform association studies on FABP5 , due to the lack of informative SNPs. FABP3 displayed no association with either disease. Each FABP is relatively small and it is assumed that there are multiple regulatory elements that control gene expression. Therefore, future identification of unknown regulatory elements will be necessary to make a more detailed analysis of their genetic contribution to mental illnesses. © 2009 Wiley‐Liss, Inc.