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Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression
Author(s) -
Neff Chris D.,
Abkevich Victor,
Potter Jennifer,
Riley Robin,
Shattuck Donna,
Katz David A.
Publication year - 2010
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30979
Subject(s) - epistasis , pedigree chart , genetics , depression (economics) , linkage (software) , allele , biology , genetic linkage , chromosome , gene , economics , macroeconomics
Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression. © 2009 Wiley‐Liss, Inc.