Evidence for epistasis between  SLC6A4  and a chromosome 4 gene as risk factors in major depression | Zendy

Neff Chris D. | Zendy; Abkevich Victor | Zendy; Potter Jennifer | Zendy; Riley Robin | Zendy; Shattuck Donna | Zendy; Katz David A. | Zendy

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Evidence for epistasis between SLC6A4 and a chromosome 4 gene as risk factors in major depression

Author(s) -

Neff Chris D.,

Abkevich Victor,

Potter Jennifer,

Riley Robin,

Shattuck Donna,

Katz David A.

Publication year - 2010

Publication title -

american journal of medical genetics part b: neuropsychiatric genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.393

H-Index - 126

eISSN - 1552-485X

pISSN - 1552-4841

DOI - 10.1002/ajmg.b.30979

Subject(s) - epistasis , pedigree chart , genetics , depression (economics) , linkage (software) , allele , biology , genetic linkage , chromosome , gene , economics , macroeconomics

Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the SLC6A4 HTTLPR short allele revealed a linkage peak on chromosome 4 (maximum HLOD = 3.5). This evidence suggests epistasis between SLC6A4 and an unknown gene as risk factors for major depression. © 2009 Wiley‐Liss, Inc.

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