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Meta‐analysis of genome‐wide linkage scans of attention deficit hyperactivity disorder
Author(s) -
Zhou Kaixin,
Dempfle Astrid,
ArcosBurgos Mauricio,
Bakker Steven C.,
Banaschewski Tobias,
Biederman Joseph,
Buitelaar Jan,
Castellanos F. Xavier,
Doyle Alysa,
Ebstein Richard P.,
Ekholm Jenny,
Forabosco Paola,
Franke Barbara,
Freitag Christine,
Friedel Susann,
Gill Michael,
Hebebrand Johannes,
Hinney Anke,
Jacob Christian,
Lesch Klaus Peter,
Loo Sandra K.,
Lopera Francisco,
McCracken James T.,
McGough James J.,
Meyer Jobst,
Mick Eric,
Miranda Ana,
Muenke Maximilian,
Mulas Fernando,
Nelson Stanley F.,
Nguyen T.Trang,
Oades Robert D.,
Ogdie Matthew N.,
Palacio Juan David,
Pineda David,
Reif Andreas,
Renner Tobias J.,
Roeyers Herbert,
Romanos Marcel,
Rothenberger Aribert,
Schäfer Helmut,
Sergeant Joseph,
Sinke Richard J.,
Smalley Susan L.,
SonugaBarke Edmund,
Steinhausen HansChristoph,
van der Meulen Emma,
Walitza Susanne,
Warnke Andreas,
Lewis Cathryn M,
Faraone Stephen V.,
Asherson Philip
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30878
Subject(s) - linkage (software) , attention deficit hyperactivity disorder , genome , genetic linkage , genetics , psychology , computational biology , biology , clinical psychology , gene
Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome‐wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome‐wide significant linkage ( P SR = 0.00034, P OR = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes. © 2008 Wiley‐Liss, Inc.