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Genetic predictors of depressive symptoms in cardiac patients
Author(s) -
McCaffery Jeanne M.,
Duan Qing Ling,
FrasureSmith Nancy,
Barhdadi Amina,
Lespérance Francois,
Théroux Pierre,
Rouleau Guy A.,
Dubé MariePierre
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30824
Subject(s) - depression (economics) , endothelial dysfunction , depressive symptoms , mechanism (biology) , disease , medicine , population , bioinformatics , psychiatry , anxiety , biology , philosophy , environmental health , epistemology , economics , macroeconomics
Numerous studies suggest that the prevalence of depression is greater among cardiac patients than in the general population. However, little attention has been paid to the possibility of genetic contributions to depressive symptoms in cardiac patients. We conducted a candidate gene study focusing on genes related to inflammation, platelet aggregation, endothelial function and omega‐3 fatty acid metabolism as predictors of depressive symptoms among 977 participants with established cardiovascular disease. Results suggested that genetic variation related to endothelial dysfunction is predictive of depressive symptoms and that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among cardiac patients. © 2008 Wiley‐Liss, Inc.