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Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach
Author(s) -
Hejjas Krisztina,
Szekely Anna,
Domotor Eszter,
Halmai Zsuzsa,
Balogh Gabriella,
Schilling Boglarka,
Sarosi Andrea,
Faludi Gabor,
SasvariSzekely Maria,
Nemoda Zsofia
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30799
Subject(s) - hospital anxiety and depression scale , allele , genotype , single nucleotide polymorphism , major depressive disorder , medicine , polymorphism (computer science) , depression (economics) , anxiety , multivariate analysis of variance , analysis of variance , gene polymorphism , psychiatry , genetics , biology , gene , macroeconomics , amygdala , machine learning , computer science , economics
The P2RX7 gene (coding for P2X7 purinergic receptor) has been suggested as a novel candidate gene for major depressive disorder (MDD) and bipolar disorder (BPD). The proposed risk allele (G‐allele) of the rs2230912 polymorphism results in an amino acid change at the 460th position, marking this genetic variation a possibly functional one. Here we present a case–control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression. While case–control analysis did not show significant difference between the groups, a significant association was found between the P2RX7 polymorphism and the HADS scales in the clinical group (MANOVA P = 0.001). Both anxiety and depression scores increased as the number of G‐allele increased in the genotype groups (ANOVA for HADS‐anxiety: P = 0.01, HADS‐depression: P < 0.001). A significant interaction of clinical status and the P2RX7 polymorphism was also found for the depression scale (MANOVA P = 0.025, subsequent ANOVA for anxiety: P = 0.252; depression: P = 0.002). Whereas patients with G‐allele‐present genotypes showed more elevated depression scores, level of depression in the control group was not affected by the P2RX7 genotype. In conclusion, case–control analysis did not reveal significant results, but using a symptom severity scale we could support the association between depressive disorder and the G‐allele of the Gln460Arg polymorphism in the P2RX7 gene. © 2008 Wiley‐Liss, Inc.