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Family‐based association study between NOS‐I and ‐IIA polymorphisms and autism spectrum disorders in Korean trios
Author(s) -
Kim HyoWon,
Cho SooChurl,
Kim JaeWon,
Cho In Hee,
Kim Soon Ae,
Park Mira,
Cho Eun Jeong,
Yoo HeeJeong
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30798
Subject(s) - transmission disequilibrium test , haplotype , single nucleotide polymorphism , autism spectrum disorder , genetics , allele , autism , allele frequency , neurodevelopmental disorder , biology , genotype , gene , psychology , psychiatry
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with a strong genetic component and environmental risk factors. Nitric oxide (NO), which is produced by nitric oxide synthase (NOS), may play a role in the development of ASD. We genotyped nine single nucleotide polymorphisms (SNPs) in the NOS‐I gene and nine SNPs in the NOS‐IIA gene and carried out the transmission disequilibrium test (TDT) and haplotype analysis in 151 Korean ASD trios. We found preferential transmission of the A allele of rs8068149 ( P = 0.039) and G allele of rs1060826 ( P = 0.035) of NOS‐IIA in ASD and the haplotype analysis revealed that the two haplotypes had significant associations ( P = 0.014 and 0.031, respectively). The behavioral subdomain score of failure to use nonverbal behaviors to regulate social interaction in Autism Diagnostic Interview‐Revised (ADI‐R) was significantly higher in subjects with the GG or AG allele in rs1060826 of NOS‐IIA compared to those who had the AA allele ( P = 0.027). These results provide significant but weak evidence for an association between NOS‐IIA and ASD in the Korean population. © 2008 Wiley‐Liss, Inc.