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Angiotensin I‐converting enzyme I/D polymorphism and suicidal behaviors
Author(s) -
Sparks D. Larry,
Hunsaker John C.,
Amouyel Philippe,
Malafosse Alain,
Bellivier Franck,
Leboyer Marion,
Courtet Philippe,
Helbecque Nicole
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30793
Subject(s) - genotype , renin–angiotensin system , allele , angiotensin converting enzyme , polymorphism (computer science) , medicine , endocrinology , psychiatry , genetics , psychology , gene , biology , blood pressure
Abstract Suicide is one of the ten most common causes of death in Western countries. It involves genetic vulnerability factors and is often associated with major depression. A Japanese team reported an association between the insertion allele of the angiotensin‐converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with completed suicide. The ACE I/D polymorphism was investigated in two independent case‐control studies, one involving 64 suicide completers and 90 controls who all underwent forensic investigations, the second one consisting of 588 suicide attempters and 639 controls. In the two population samples studied a statistically significant risk of suicidal behavior was observed for subjects bearing the DD genotype. These results suggest a possible role of the renin‐angiotensin system in suicidal behavior. © 2008 Wiley‐Liss, Inc.