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No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population
Author(s) -
Kawashima Kunihiro,
Kishi Taro,
Ikeda Masashi,
Kitajima Tsuyoshi,
Yamanouchi Yoshio,
Kinoshita Yoko,
Takahashi Nagahide,
Saito Shinichi,
Ohi Kazutaka,
Yasuda Yuka,
Hashimoto Ryota,
Takeda Masatoshi,
Inada Toshiya,
Ozaki Norio,
Iwata Nakao
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30781
Subject(s) - single nucleotide polymorphism , genetics , biology , haplotype , snap25 , linkage disequilibrium , population , snp , genetic association , gene , allele , medicine , synaptic vesicle , genotype , vesicle , environmental health , membrane
Abnormalities in neural connections and the neurotransmitter system appear to be involved in the pathophysiology of schizophrenia. The soluble N ‐ethylmaleimide‐sensitive factor attachment protein receptor (SNARE) complex, which consists of Syntaxin1A, vesicle‐associated membrane protein 2 (VAMP2) and synaptosomal‐associated protein 25 kDa (SNAP25), plays an important role in the neurotransmitter system, and is therefore an attractive place to search for candidate genes for schizophrenia. We conducted a two‐stage genetic association analysis of Syntaxin1A ( STX1A ), VAMP2 and SNAP25 genes with schizophrenia (first‐set screening samples: 377 cases and 377 controls, second‐set confirmation samples: 657 cases and 527 controls). Based on the linkage disequilibrium, 40 SNPs ( STX1A , 8 SNPs; VAMP2 , 3 SNPs; SNAP25 , 29 SNPs) were selected as ‘tagging SNPs’. Only nominally significant associations of an SNP (rs12626080) and haplotype (rs363014 and rs12626080) in SNAP25 were detected in the first‐set screening scan. To validate this significance, we carried out a replication analysis of these SNP and haplotype associations in second‐set samples with a denser set of markers (including five additional SNPs). However, these associations could not be confirmed in the second‐set analysis. These results suggest that the SNARE complex‐related genes do not play a major role in susceptibility to schizophrenia in the Japanese population. © 2008 Wiley‐Liss, Inc.