Premium
Criteria for validating mouse models of psychiatric diseases
Author(s) -
Chadman Kathryn K.,
Yang Mu,
Crawley Jacqueline N.
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30777
Subject(s) - human disease , phenotype , animal model , disease , gene , clinical phenotype , computational biology , neuroscience , biology , bioinformatics , psychology , genetics , medicine , pathology , endocrinology
Abstract Animal models of human diseases are in widespread use for biomedical research. Mouse models with a mutation in a single gene or multiple genes are excellent research tools for understanding the role of a specific gene in the etiology of a human genetic disease. Ideally, the mouse phenotypes will recapitulate the human phenotypes exactly. However, exact matches are rare, particularly in mouse models of neuropsychiatric disorders. This article summarizes the current strategies for optimizing the validity of a mouse model of a human brain dysfunction. We address the common question raised by molecular geneticists and clinical researchers in psychiatry, “what is a ‘good enough’ mouse model”11 Published 2008 Wiley‐Liss, Inc.