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Association analysis of dynamin‐binding protein ( DNMBP ) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample
Author(s) -
Morgan A.R.,
Hollingworth P.,
Abraham R.,
Lovestone S.,
Brayne C.,
Rubinsztein D.C.,
Lynch A.,
Lawlor B.,
Gill M.,
O'Donovan M.C.,
Owen M.J.,
Williams J.
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30768
Subject(s) - single nucleotide polymorphism , genetics , snp , allele , genotype , biology , linkage disequilibrium , allele frequency , genetic association , population , medicine , gene , environmental health
A recent scan of single nucleotide polymorphisms (SNPs) in the region 40–107 Mb on chromosome 10q in a large Japanese case–control cohort identified six SNPs in or near the dynamin‐binding protein gene ( DNMBP ) that were associated with late onset Alzheimer's disease (LOAD) in individuals lacking the APOE ε4 allele [Kuwano et al. (2006); Hum Mol Genet 15:2170–2182]. We genotyped these six SNPs in 1,212 unrelated Caucasian patients of UK origin with LOAD and 1,389 ethnically, gender and age matched control subjects. We did not observe a statistically significant association with the risk of LOAD for any of the six SNPs in the sample as a whole. When stratifying the sample by APOE one SNP (intergenic SNP rs11190302) was associated with LOAD in individuals lacking the ε4 allele (genotypic P = 0.027, allelic P = 0.066). However this association was in the opposite direction to that detected in the Japanese population. It remains to be determined whether DNMBP is associated with LOAD. © 2008 Wiley‐Liss, Inc.