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No pathogenic rearrangement within the DISC 1 gene in psychosis
Author(s) -
Legallic Solenn,
Bou Jacqueline,
Haouzir Sadeq,
Allio Gabrielle,
Demily Caroline,
Petit Michel,
Frebourg Thierry,
Thibaut Florence,
Campion Dominique
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30753
Subject(s) - schizophrenia (object oriented programming) , psychosis , chromosomal translocation , bipolar disorder , schizoaffective disorder , pathological , psychiatry , psychology , medicine , gene , genetics , biology , cognition
A translocation disrupting the DISC 1 gene segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Mutation screening of this gene by routine PCR‐based methods has remained largely negative. We sought to detect rearrangements affecting DISC 1 in 347 individuals meeting the DSM3R criteria for schizophrenia or schizoaffective disorder, 70 subjects with bipolar disorder and 377 psychiatrically healthy controls, but failed to detect any pathological rearrangement. © 2008 Wiley‐Liss, Inc.