Premium
Association study between polymorphisms in glutathione‐related genes and methamphetamine use disorder in a Japanese population
Author(s) -
Hashimoto Tasuku,
Hashimoto Kenji,
Miyatake Ryosuke,
Matsuzawa Daisuke,
Sekine Yoshimoto,
Inada Toshiya,
Ozaki Norio,
Iwata Nakao,
Harano Mutsuo,
Komiyama Tokutaro,
Yamada Mitsuhiko,
Sora Ichiro,
Ujike Hiroshi,
Iyo Masaomi
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30703
Subject(s) - meth , odds ratio , methamphetamine , genotype , glutathione , medicine , population , psychosis , genetics , pharmacology , biology , gene , psychiatry , chemistry , enzyme , biochemistry , environmental health , acrylate , polymer , monomer , organic chemistry
Accumulating evidence suggests that oxidative stress plays a role in the mechanisms of action of methamphetamine (METH) in the brain. In the present study, we investigated the association between the genetic polymorphisms among glutathione (GSH)‐related enzymes; glutathione S ‐transferases (GSTs) such as GSTT1 (Non‐deletion/Null), GSTT2 (Met139Ile), GSTA1 (−69C/T), and GSTO1 (Ala140Asp); glutathione peroxidase 1 (GPX1) (Pro198Leu); and glutamate‐cysteine ligase modifier (GCLM) subunit and METH use disorder in a Japanese population. Two hundred eighteen METH abusers and 233 healthy controls were enrolled in the study. There was a significant difference in GSTT1 genotype frequency between patients with METH psychosis and controls ( P = 0.039, odds ratio: 1.52, 95% CI 1.03–2.24). Furthermore, the frequency (66.0%) of the GSTT1 null genotype among prolonged‐type METH psychotic patients with spontaneous relapse was significantly higher ( P = 0.025, odds ratio: 2.43, 95% CI 1.13–5.23) than that (44.4%) of transient‐type METH psychotic patients without spontaneous relapse. However, there were no associations between the polymorphisms of other genes and METH abuse. The present study suggests that the polymorphism of the GSTT1 gene might be a genetic risk factor of the development of METH psychosis in a Japanese population. © 2008 Wiley‐Liss, Inc.