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Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder
Author(s) -
Prata Diana,
Breen Gerome,
Osborne Sarah,
Munro Janet,
St. Clair David,
Collier David
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30682
Subject(s) - haplotype , single nucleotide polymorphism , genetics , snp , bipolar disorder , candidate gene , biology , genetic association , gene , genotype , endocrinology , lithium (medication)
Abstract There is growing evidence of partial aetiological overlap between schizophrenia and bipolar disorder (BP) from linkage analysis, genetic epidemiology and molecular genetics studies. In the present study we investigated whether individual polymorphisms or haplotypes of the DAO and G72(DAOA)/G30 genes, which have been previously implicated in schizophrenia, are also associated with bipolar disorder. For each gene, we genotyped 213 cases and 197 controls for SNPs previously associated with schizophrenia: rs2111902 (MDAAO‐4), rs3918346 (MDAAO‐5), rs3741775 (MDAAO‐6) and rs3918347 (MDAAO‐7) in DAO and rs746187 (M7), rs3916966 (M13), rs2391191 (M15) and rs3916972 (M25) in G72. Although none of the individual SNPs in these genes reached statistical significance, we found haplotype wise associations with bipolar disorder for both genes. These included a two‐SNP haplotype in DAO (rs2111902‐A and rs3918346‐T; global P = 0.003, individual P = 0.002, Z = 3.1) and a two‐SNP haplotype for G72(DAOA)/G30 (rs746187‐G and rs3916972‐G; global P = 0.05; individual P = 0.005, Z = 2.81). However, we found no evidence for an epistatic interaction between the SNPs and/or haplotypes of the two genes. In summary, our findings provide some support for the individual involvement of DAO and G72(DAOA)/G30 in the etiology of bipolar disorder. © 2007 Wiley‐Liss, Inc.