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Two methylenetetrahydrofolate reductase gene ( MTHFR ) polymorphisms, schizophrenia and bipolar disorder: An association study
Author(s) -
Jönsson Erik G,
Larsson Kristina,
Vares Maria,
Hansen Thomas,
Wang August G.,
Djurovic Srdjan,
Rønningen Kjersti S.,
Andreassen Ole A.,
Agartz Ingrid,
Werge Thomas,
Terenius Lars,
Hall Håkan
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30671
Subject(s) - methylenetetrahydrofolate reductase , single nucleotide polymorphism , bipolar disorder , genetics , schizophrenia (object oriented programming) , allele , genotype , norwegian , genetic association , gene , medicine , biology , psychiatry , cognition , linguistics , philosophy
Recent meta‐analyses of the methylenetetrahydrofolate reductase gene ( MTHFR ) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case‐control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case‐control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta‐analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships. © 2007 Wiley‐Liss, Inc.