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No association of genetic variants of liver X receptor‐β with alzheimer's disease risk
Author(s) -
RodríguezRodríguez Eloy,
Llorca Javier,
Mateo Ignacio,
Infante Jon,
SánchezQuintana Coro,
GarcíaGorostiaga Inés,
FernándezViadero Carlos,
Peña Nicolás,
Berciano José,
Combarros Onofre
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30652
Subject(s) - apolipoprotein e , liver x receptor , allele , haplotype , genotype , biology , alzheimer's disease , genetics , genetic association , medicine , endocrinology , gene , disease , single nucleotide polymorphism , transcription factor , nuclear receptor
Apolipoprotein E ( APOE ) ε4 allele is the strongest hitherto known risk factor for sporadic Alzheimer's disease (AD). Liver X receptor‐β (LXRβ) is a transcription factor that controls expression of genes involved in brain cholesterol metabolism, and one of the main LXRβ targets is APOE. To evaluate the relationship between LXRβ genetic variants and AD, independently or in concert with the APOE ε4 allele, we examined three LXRβ polymorphisms located in introns 2 (rs 2695121), 5 (rs 1052533), and 7 (rs 1405655), in 414 Spanish AD patients and 447 controls. The current study does not demonstrate an association between LXRβ genotypes or haplotypes and AD, neither in the total sample nor when the populations were stratified for the presence or absence of the APOE ε4 allele. © 2007 Wiley‐Liss, Inc.