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PRODH gene is associated with executive function in schizophrenic families
Author(s) -
Li Tao,
Ma Xiaohong,
Hu Xun,
Wang Yingcheng,
Yan Chengying,
Meng Huaqing,
Liu Xiehe,
Toulopoulou Timothea,
Murray Robin M.,
Collier David A.
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30648
Subject(s) - neurocognitive , single nucleotide polymorphism , haplotype , genetic association , genetics , psychology , gene , allele , cognition , biology , genotype , psychiatry
The aim of this study was to investigate the relationship between polymorphisms in the PRODH and COMT genes and selected neurocognitive functions. Six SNPs in PRODH and two SNPs in COMT were genotyped in 167 first‐episode schizophrenic families who had been assessed by a set of 14 neuropsychological tests. Neuropsychological measures were selected as quantitative traits for association analysis. The haplotype of SNPs PRODH 1945T/C and PRODH 1852G/A was associated with impaired performance on the Tower of Hanoi, a problem‐solving task mainly reflecting planning capacity. There was no significant evidence for association with any other neuropsychological traits for other SNPs or haplotypes of paired SNPs in the two genes. This study takes previous findings of association between PRODH and schizophrenia further by associating variation within the gene with performance on a neurocognitive trait characteristic of the illness. It fails to confirm previous reports of an association between COMT and cognitive function. © 2007 Wiley‐Liss, Inc.