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Linkage analysis of attention deficit hyperactivity disorder
Author(s) -
Faraone Stephen V.,
Doyle Alysa E.,
LaskySu Jessica,
Sklar Pamela B.,
D'Angelo Eugene,
GonzalezHeydrich Joseph,
Kratochvil Christopher,
Mick Eric,
Klein Kristy,
Rezac Amy J.,
Biederman Joseph
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30631
Subject(s) - genetic linkage , linkage (software) , genetics , sibling , phenotype , biology , candidate gene , chromosome , lod score , gene , psychology , developmental psychology , gene mapping
Abstract Results of behavioral genetic and molecular genetic studies have converged to suggest that both genes contribute to the development of ADHD. Although prior linkage studies have produced intriguing results, their results have been inconsistent, with no clear pattern of results emerging across studies. We genotyped 5,980 SNPs across the genome in 1,187 individuals from families with children diagnosed with ADHD. We then performed two nonparametric linkage analyses on ADHD families: (1) an affected sibling pair linkage analysis on 217 families with 601 siblings diagnosed with ADHD and (2) a variance components linkage analysis using the number of ADHD symptoms as the phenotype on 260 families with 1,100 phenotyped siblings. The affection status linkage analysis had a maximum LOD score of 1.85 on chromosome 8 at 54.2 cM. The maximum LOD score in the variance components linkage analysis was 0.8 on chromosome 8 at 93.4 cM. The absence of regions of significant or suggestive linkage in these data suggest that there are no genes of large effect contributing to the ADHD phenotype. © 2007 Wiley‐Liss, Inc.