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The association between DRD2/ANKK1, 5‐HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan
Author(s) -
Wu ChinYeh,
Wu YiSyuan,
Lee JiaFu,
Huang SanYuan,
Yu Lung,
Ko HueiChen,
Lu RuBand
Publication year - 2008
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30626
Subject(s) - harm avoidance , novelty seeking , antisocial personality disorder , psychology , reward dependence , population , clinical psychology , psychiatry , personality , big five personality traits , poison control , injury prevention , medicine , social psychology , environmental health
Cloninger suggested that type II alcoholism was associated with higher novelty seeking and less harm avoidance behaviors, which was similar to antisocial alcoholism. Most previous studies have failed to recruit subjects that have antisocial personality disorder without alcoholism due to the high coexisting likelihood of having antisocial personality disorder with alcoholism in the majority of the examined populations. Thus, recruitment of individuals with antisocial non‐alcoholism (antisocial personality disorder) served as an important control group in examining Cloninger's hypothesis. Due to the documented protective effects against alcoholism of ALDH2*1/*2 or *2/*2 genotype among the Han Chinese population, we recruited antisocial non‐alcoholics from the Han Chinese population in Taiwan to verify Cloninger's hypotheses. A total of 127 Han Chinese subjects were recruited who met the diagnosis of antisocial alcoholism (n = 43) or antisocial non‐alcoholism (n = 84). We found that the antisocial alcoholism group scored higher on the novelty seeking behavior than did the antisocial non‐alcoholism group (t = 2.61, P = 0.01), but no difference was observed on the harm avoidance dimension between these two groups (t = 0.15, P = 0.88). In the novelty seeking scores, after stratification of DRD2 Taq I A genotypes, only a significant difference in 5‐HTTLPR polymorphisms between antisocial alcoholics and antisocial non‐alcoholics was found, indicating an interaction between DRD2 Taq I A1+ (include A1 / A1 or A1 / A2 ) and 5‐HTTLPR S / S genotype (t = 2.75, P = 0.01) However, no significant difference was found in the harm avoidance personality trait between these two groups of Han Chinese in Taiwan. © 2007 Wiley‐Liss, Inc.