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Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior
Author(s) -
Giegling Ina,
MorenoDeLuca Daniel,
Rujescu Dan,
Schneider Barbara,
Hartmann Annette M.,
Schnabel Axel,
Maurer Konrad,
Möller HansJürgen,
Serretti Alessandro
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30599
Subject(s) - aggression , tyrosine hydroxylase , psychology , dopaminergic , clinical psychology , suicide attempt , schizophrenia (object oriented programming) , aromatic l amino acid decarboxylase , psychiatry , poison control , medicine , suicide prevention , dopamine , neuroscience , medical emergency
The dopaminergic system has been previously associated to behavioral facilitation and aggression, hence making the pathway a good candidate for suicidal behavior. We studied gene variants in the tyrosine hydroxylase (rs3842727, rs6356) and DOPA decarboxylase (rs1451371, rs1470750, rs998850) genes in a sample of 571 individuals consisting of 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide and 312 German control subjects. TH variants were not associated with suicide (uncorrected P = 0.023) and related traits. Some marginal associations could be observed for DDC with suicide, violence, anger, and aggression. In conclusion, our study does not support the involvement of TH gene variants as major contributors to suicide, whereas DDC variants could mediate some features related to suicide and be involved in violent suicidal behavior. © 2007 Wiley‐Liss, Inc.