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No association between common variants in glyoxalase 1 and autism spectrum disorders
Author(s) -
Rehnström Karola,
Ylisaukkooja Tero,
Vanhala Raija,
von Wendt Lennart,
Peltonen Leena,
Hovatta Iiris
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30582
Subject(s) - autism , genetics , candidate gene , genetic association , heritability of autism , snp , biology , gene , population , association (psychology) , polymorphism (computer science) , genetic linkage , autism spectrum disorder , single nucleotide polymorphism , medicine , psychology , genotype , psychiatry , environmental health , psychotherapist
The autism spectrum disorders (ASDs) are complex diseases with a strong genetic component. Numerous candidate gene studies have tested association between various functional and positional candidate genes and autism, but no common variation predisposing for autism has been identified to date. It has been previously proposed, that glyoxalase 1 (GLO1) might be involved in the pathogenesis of autism as GLO1 protein polarity was significantly changed in the brains of autism patients compared to controls. GLO1 harbors a functional polymorphism that affects the polarity and the enzymatic activity of the protein. In the same study, this polymorphism showed a suggestive association to autism. To investigate whether common variants in GLO1 predispose to autism in the Finnish population, we have genotyped six polymorphisms in GLO1 in families with more than 230 individuals affected with ASDs and carried out both linkage and association analyses. We did not observe significant linkage or association between any SNP and ASDs. Therefore, we suggest that common variants in GLO1 are not significant susceptibility factors for ASDs in the Finnish population. © 2007 Wiley‐Liss, Inc.