Premium
Testing for gene × environment interaction effects in attention deficit hyperactivity disorder and associated antisocial behavior
Author(s) -
Langley K.,
Turic D.,
Rice F.,
Holmans P.,
van den Bree M.B.M.,
Craddock N.,
Kent L.,
Owen M.J.,
O'Donovan M.C.,
Thapar A.
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30571
Subject(s) - attention deficit hyperactivity disorder , conduct disorder , etiology , logistic regression , gene–environment interaction , psychology , birth weight , pregnancy , clinical psychology , psychiatry , medicine , gene , genetics , biology , genotype
Gene × environment (G × E) interactions are increasingly thought to have substantial influence on the aetiology and clinical manifestations of complex disorders. In ADHD, although main effects of specific genetic variants and pre‐ or peri‐natal variables have been reported and replicated using pooled analyses, few studies have looked at possible interactions. In a clinical sample of 266 children with ADHD, we tested for interaction between gene variants (in DRD4, DAT1, DRD5, and 5HTT) found to be associated with ADHD in pooled analyses and maternal smoking, alcohol use during pregnancy and birth weight. First, G × E effects on a diagnosis of ADHD were tested using conditional logistic regression analyses. Second, possible modifying effects of G × E on symptoms of associated conduct disorder and oppositional defiant disorder (ODD) were investigated using linear regression analysis. The sample size associated with each of the analyses differed as not each variant had been genotyped for each individual. No effects of G × E on ADHD diagnosis were observed. The results suggest that lower birth weight and maternal smoking during pregnancy may interact with DRD5 and DAT1 (birth weight only) in influencing associated antisocial behavior symptoms (ODD and conduct disorder). These preliminary findings showed no evidence of interaction between previously implicated variants in ADHD and specific environmental risk factors, on diagnosis of the disorder. There may be evidence of G × E on associated antisocial behavior in ADHD, but further investigation is needed. © 2007 Wiley‐Liss, Inc.