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Porcine maternal infanticide as a model for puerperal psychosis
Author(s) -
Quilter Claire R.,
Blott Sarah C.,
Wilson Anna E.,
Bagga Meenakshi R.,
Sargent Carole A.,
Oliver Gina L.,
Southwood Olwen I.,
Gilbert Colin L.,
Mileham Alan,
Affara Nabeel A.
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30529
Subject(s) - quantitative trait locus , psychosis , autosome , genetics , genetic linkage , biology , offspring , microsatellite , chromosome , psychology , pregnancy , allele , psychiatry , gene
Childbirth is a period of substantial rapid biological and psychological change and a wide range of psychotic disorders can occur ranging from mild ‘baby blues’ to severe episodes of psychotic illnesses. Puerperal psychosis is the most extreme form of postnatal psychosis, occurring in 1 in 1,000 births. In this study, we have used the pig as an animal model for human postnatal psychiatric illness. Our aim was to identify quantitative trait loci (QTL) associated with maternal (infanticide) sow aggression. This is defined by sows attacking and killing their own newborn offspring, within 24 hr of birth. An affected sib pair whole genome linkage analysis was carried out with 80 microsatellite markers covering the 18 porcine autosomes and the X chromosome, with the aim of identifying chromosomal regions responsible for this abnormal behavior. Analysis was carried out using the non‐parametric linkage test of Whittemore and Halpern, as implemented in the Merlin software. The results identified 4 QTL mapping on Sus scrofa chromosomes 2 (SSC2), 10 (SSC10), and X (SSCX). The peak regions of these QTL are syntenic to HSA 5q14.3‐15, 1q32, Xpter‐Xp2.1, and Xq2.4‐Xqter, respectively. Several potential candidate genes lie in these regions in addition to relevant abnormal behavioral QTL, found in humans and rodents. © 2007 Wiley‐Liss, Inc.