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Investigation of parent‐of‐origin effects in ADHD candidate genes
Author(s) -
Kim Jang Woo,
Waldman Irwin D.,
Faraone Stephen V.,
Biederman Joseph,
Doyle Alysa E.,
Purcell Shaun,
Arbeitman Lori,
Fagerness Jesen,
Sklar Pamela,
Smoller Jordan W.
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30519
Subject(s) - candidate gene , attention deficit hyperactivity disorder , allele , genetics , gene , biology , psychology , clinical psychology
Attention deficit hyperactivity disorder (ADHD) is a common early‐onset childhood disorder with a strong genetic component. Results from previous studies have suggested that there may be a parent‐of‐origin effect for ADHD candidate genes. In particular, a recent investigation identified a pattern of paternal over‐transmission of risk alleles for nine ADHD candidate genes. We examined this phenomenon in a sample of 291 trios for five genes previously associated with ADHD (HTR1B, SNAP‐25, DRD5, DAT1, and BDNF). Using a dense map of markers and two analytic methods in this relatively large family‐based sample, we do not find any evidence for significant paternal over‐transmission of risk alleles in these candidate loci. Thus, we conclude that a substantial parent‐of‐origin effect is unlikely for these leading ADHD candidate genes. © 2007 Wiley‐Liss, Inc.