Premium
Tachykinin receptor 1 variants associated with aggression in suicidal behavior
Author(s) -
Giegling Ina,
Rujescu Dan,
Mandelli Laura,
Schneider Barbara,
Hartmann Annette M.,
Schnabel Axel,
Maurer Konrad,
De Ronchi Diana,
Möller HansJürgen,
Serretti Alessandro
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30506
Subject(s) - impulsivity , aggression , psychology , clinical psychology , suicidal ideation , anxiety , poison control , borderline personality disorder , anger , psychiatry , suicide prevention , medicine , environmental health
Substance P is involved in the modulation of depression, anxiety, and suicidal‐related behaviors. We studied gene variants of Tachykinin Receptor 1 (TACR1—rs3771810, rs3771825, rs726506, rs1477157) in 167 German suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 Caucasian individuals who committed suicide and 312 German healthy subjects. Single markers and haplotype analysis in relation to suicidal behaviors (suicide attempters/completers) did not reveal any significant association. The rarest rs3771825 T allele however showed a marginal association with higher Reactive Aggression scores on the Questionnaire for Measuring Factors of Aggression (FAF) (F = 9.86, df = 1; P = 0.0017). Haplotype analyses confirmed the finding. Violence or impulsivity of suicide attempt and State‐Trait Anger Expression Inventory (STAXI) scores were not associated with gene variants. In conclusion, our study suggests that TACR1 gene variants have no major influence on suicidal behavior but may modulate aggression features. © 2007 Wiley‐Liss, Inc.