Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for  SOS2 ,  PCK1 , and  PPARγ  as susceptibility loci | Zendy

Hamilton Gillian | Zendy; Proitsi Petra | Zendy; Jehu Luke | Zendy; Morgan Angharad | Zendy; Williams Julie | Zendy; O'Donovan Michael C. | Zendy; Owen Michael J. | Zendy; Powell John F. | Zendy; Lovestone Simon | Zendy

Premium

Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2 , PCK1 , and PPARγ as susceptibility loci

Author(s) -

Hamilton Gillian,

Proitsi Petra,

Jehu Luke,

Morgan Angharad,

Williams Julie,

O'Donovan Michael C.,

Owen Michael J.,

Powell John F.,

Lovestone Simon

Publication year - 2007

Publication title -

american journal of medical genetics part b: neuropsychiatric genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.393

H-Index - 126

eISSN - 1552-485X

pISSN - 1552-4841

DOI - 10.1002/ajmg.b.30503

Subject(s) - single nucleotide polymorphism , haplotype , genetics , disease , genetic association , biology , candidate gene , gene , alzheimer's disease , snp , genome wide association study , genotype , medicine

Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late‐onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two‐stage approach to identify novel risk factors for LOAD. One hundred fifty‐two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes— PPARγ , SOS2 , and PCK1 —with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. © 2007 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research