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Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2 , PCK1 , and PPARγ as susceptibility loci
Author(s) -
Hamilton Gillian,
Proitsi Petra,
Jehu Luke,
Morgan Angharad,
Williams Julie,
O'Donovan Michael C.,
Owen Michael J.,
Powell John F.,
Lovestone Simon
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30503
Subject(s) - single nucleotide polymorphism , haplotype , genetics , disease , genetic association , biology , candidate gene , gene , alzheimer's disease , snp , genome wide association study , genotype , medicine
Epidemiological evidence supports the existence of a possible link between type II diabetes mellitus (T2DM) and late‐onset Alzheimer's disease (LOAD). Polymorphisms from candidate genes for T2DM were genotyped in a two‐stage approach to identify novel risk factors for LOAD. One hundred fifty‐two polymorphisms were initially genotyped in a case:control cohort: nine SNPs showed individual association with disease status under at least one genetic model, while an additional two SNPs showed a haplotype association. In a replication study, we confirmed significant association of SNPs within three genes— PPARγ , SOS2 , and PCK1 —with Alzheimer's disease. In particular, our data suggest that the effect of variants within these genes might be influenced by gender. © 2007 Wiley‐Liss, Inc.