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Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia
Author(s) -
Brkanac Zoran,
Chapman Nicola H.,
Matsushita Mark M.,
Chun Lani,
Nielsen Kathleen,
Cochrane Elizabeth,
Berninger Virginia W.,
Wijsman Ellen M.,
Raskind Wendy H.
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30471
Subject(s) - dyslexia , proband , candidate gene , genetics , locus (genetics) , transmission disequilibrium test , genetic linkage , linkage disequilibrium , allele , biology , psychology , developmental dyslexia , genetic association , gene , genotype , haplotype , single nucleotide polymorphism , reading (process) , political science , law , mutation
Dyslexia is a common heterogeneous disorder with a significant genetic component. Multiple studies have replicated the evidence for linkage between variously defined phenotypes of dyslexia and chromosomal regions on 15q21 ( DYX1 ) and 6p22.2 ( DYX2 ). Based on association studies and the possibility for functional significance of several polymorphisms, candidate genes responsible for the observed linkage signal have been proposed— DYX1C1 for 15q21, and KIAA0319 and DCDC2 for 6p22.2. We investigated the evidence for contribution of these candidate genes to dyslexia in our sample of multigenerational families. Our previous quantitative linkage analyses in this dataset provided supportive evidence for linkage of dyslexia to the locus on chromosome 15, but not to the locus on chromosome 6. In the current study, we used probands from 191 families for a case control analysis, and proband‐parent trios for family‐based TDT analyses. The observation of weak evidence for transmission disequilibrium for one of the two studied polymorphisms in DYX1C1 suggests involvement of this gene in dyslexia in our dataset. We did not find evidence for the association of KIAA0319 or DCDC2 alleles to dyslexia in our sample. We observed a slight tendency for an intronic deletion in DCDC2 to be associated with worse performance on some quantitative measures of dyslexia in the probands in our sample, but not in their parents. © 2007 Wiley‐Liss, Inc.