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Synaptotagmin XI as a candidate gene for susceptibility to schizophrenia
Author(s) -
Inoue Shinichi,
Imamura Akira,
Okazaki Yuji,
Yokota Hiroshi,
Arai Makoto,
Hayashi Naoki,
Furukawa Aizo,
Itokawa Masanari,
Oishi Michio
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30465
Subject(s) - synaptotagmin 1 , locus (genetics) , gene , genetics , biology , single nucleotide polymorphism , promoter , yy1 , untranslated region , microbiology and biotechnology , gene expression , messenger rna , synaptic vesicle , genotype , vesicle , membrane
Synaptotagmin XI ( Syt11 ) is a member of the synaptotagmin family, which is localized in cells either in synaptic vesicles or the cellular membrane, and is known to act as a calcium sensor. The Syt11 gene is located on chromosome locus 1q21‐q22, which was previously reported as a major susceptibility locus of familial schizophrenia. Here, we present evidence for an association between the number of 33‐bp repeats in the promoter region of the Syt11 gene and schizophrenia. We found that the transcriptional activity of the gene is affected by the number of 33‐bp repeats, which include an Sp1 binding site, suggesting that the excessive expression of Syt11 can be associated with schizophrenia. Another (single nucleotide) polymorphism in the Syt11 5′UTR region, where the potent transcription factor YY1 can bind, also affects the transcriptional activity of Syt11 . © 2006 Wiley‐Liss, Inc.