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Association of dopamine transporter genotype with disruptive behavior disorders in an eight‐year longitudinal study of children and adolescents
Author(s) -
Lee Steve S.,
Lahey Benjamin B.,
Waldman Irwin,
Van Hulle Carol A.,
Rathouz Paul,
Pelham William E.,
Loney Jan,
Cook Edwin H.
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30447
Subject(s) - dopamine transporter , variable number tandem repeat , impulsivity , association (psychology) , allele , attention deficit hyperactivity disorder , psychology , genotype , longitudinal study , dopamine , medicine , psychiatry , genetics , biology , neuroscience , gene , dopaminergic , pathology , psychotherapist
Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8‐year longitudinal study of children (n = 183). Half of the children met criteria for attention‐deficit/hyperactivity disorder (ADHD) at 4–6 years and half were non‐referred comparison children. Consistent with several studies, the non‐additive association for the 10‐repeat allele was significant for hyperactivity‐impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non‐additive association of the 9‐repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10‐repeat and 9‐repeat alleles. © 2006 Wiley‐Liss, Inc.