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Effect of 5‐haplotype of dysbindin gene ( DTNBP1 ) polymorphisms for the susceptibility to bipolar I disorder
Author(s) -
Pae ChiUn,
Serretti Alessandro,
Mandelli Laura,
Yu HyeSook,
Patkar Ashwin A.,
Lee ChangUk,
Lee SooJung,
Jun TaeYoun,
Lee Chul,
Paik InHo,
Kim JungJin
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30439
Subject(s) - haplotype , genetics , bipolar disorder , biology , gene , allele , neuroscience , cognition
We investigated a possible association between dysbindin gene ( DTNBP1) variants and bipolar I disorder (BID). Five SNPs within DTNBP1 (rs3213207, rs1011313, rs2005976, rs760761, and rs2619522) were genotyped for 151 patients with BID and 478 controls. We observed a significant protective association of the haplotype A‐C‐G‐T‐A (all SNPs, P = 0.00016) and particularly G‐T‐A (the last three SNP, P = 0.00007) within DTNBP1 variants investigated. Single marker and subgroup (e.g., psychotic features, age at onset, family history, etc.) analyses showed no significant association. Although the association was due to a small number of subjects, specific DTNBP1 haplotypes, previously associated with schizophrenia, may be also associated with BID. Adequately powered studies from different ethnicities will be necessary to confirm our findings. © 2006 Wiley‐Liss, Inc.