Effect of 5‐haplotype of dysbindin gene ( DTNBP1 ) polymorphisms for the susceptibility to bipolar I disorder

We investigated a possible association between dysbindin gene ( DTNBP1) variants and bipolar I disorder (BID). Five SNPs within DTNBP1 (rs3213207, rs1011313, rs2005976, rs760761, and rs2619522) were genotyped for 151 patients with BID and 478 controls. We observed a significant protective association of the haplotype A‐C‐G‐T‐A (all SNPs, P  = 0.00016) and particularly G‐T‐A (the last three SNP, P  = 0.00007) within DTNBP1 variants investigated. Single marker and subgroup (e.g., psychotic features, age at onset, family history, etc.) analyses showed no significant association. Although the association was due to a small number of subjects, specific DTNBP1 haplotypes, previously associated with schizophrenia, may be also associated with BID. Adequately powered studies from different ethnicities will be necessary to confirm our findings. © 2006 Wiley‐Liss, Inc.