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Tumor necrosis factor‐α promoter polymorphism is associated with the risk of Parkinson's disease
Author(s) -
Wu YihRu,
Feng IHsin,
Lyu RongKuo,
Chang KuoHsuan,
Lin YuYun,
Chan Huiling,
Hu FenJu,
LeeChen GueyJen,
Chen ChiungMei
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30435
Subject(s) - linkage disequilibrium , haplotype , single nucleotide polymorphism , odds ratio , genotype , snp , medicine , pathogenesis , cohort , tag snp , gastroenterology , case control study , genetics , immunology , oncology , biology , gene
Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case‐control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor‐α ( TNF‐α ) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T‐1031C and C‐857T sites showed significant difference between PD cases and controls ( P = 0.0062 and 0.0035, respectively). However, only the more frequent −1031 CC genotype was evidently associated with PD ( P = 0.0085, odds ratio: 2.96; 95% CI: 1.38–7.09). Pairwise SNP linkage disequilibrium showed −1031 and −863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ 2 = 0.80). Pairwise haplotype analysis among the four sites showed that −1031C‐863A may act as a risk haplotype among PD cases ( P = 0.0028, odds ratio: 2.18; 95% CI: 1.33–3.69). © 2006 Wiley‐Liss, Inc.