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Obsessive‐compulsive disorder is not a clinical manifestation of the DYT1 dystonia gene
Author(s) -
Heiman Gary A.,
Ottman Ruth,
SaundersPullman Rachel J.,
Ozelius Laurie J.,
Risch Neil J.,
Bressman Susan B.
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30431
Subject(s) - dystonia , obsessive compulsive , mutation , medicine , psychiatry , psychology , gene , genetics , biology
Abstract Prior studies suggest that obsessive‐compulsive symptoms (OCS) and disorder (OCD) are co‐morbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non‐manifesting carriers (NMC), and non‐carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia. © 2006 Wiley‐Liss, Inc.