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Association analysis of GABA receptor subunit genes on 5q33 with heroin dependence in a Chinese male population
Author(s) -
Loh E.W.,
Tang N.L.S.,
Lee D.T.S.,
Liu S.I.,
Stadlin Alfreda
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30429
Subject(s) - single nucleotide polymorphism , gabbr1 , protein subunit , genetics , gaba receptor , allele , gene , biology , gabaa receptor , medicine , receptor , endocrinology , pharmacology , genotype , 5 ht5a receptor , protease activated receptor 2
GABA A receptor subunit genes clustered on 5q33 play a role in the development of alcoholism and methamphetamine use disorder without psychosis. The present study explored the possible contribution of the same subunit genes to the development of heroin dependence. Single nucleotide polymorphisms (SNPs) of the GABA A receptor subunits GABRB2, GABRA6, GABRA1, and GABRG2 were examined in 178 male Han Chinese heroin‐dependent and 170 male control subjects. A significant difference in allele frequency for the SNP rs211014 in the GABA A γ2 receptor subunit gene between cases and controls was identified ( P = 0.015). A possible mechanism for the involvement of the GABA receptor subunit genes on 5q33 in the development of heroin dependence is discussed. © 2007 Wiley‐Liss, Inc.