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p75 NTR gene and suicide attempts in young adults with a history of childhood‐onset mood disorder
Author(s) -
McGregor S.,
Strauss J.,
Bulgin N.,
De Luca V.,
George C.J.,
Kovacs M.,
Kennedy J.L.
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30418
Subject(s) - mood disorders , biology , missense mutation , genetics , mood , gene , medicine , psychiatry , phenotype , anxiety
Recently, evidence has accumulated for the role of neurotrophic processes in mood disorders. Neurotrophins operate on receptors, one of which is the p75 neurotrophin receptor (p75 NTR ). We examined three p75 NTR markers at the p75 NTR gene, including a missense polymorphism that changes serine to leucine (S205L), for association with suicide attempt (SA) in 203 childhood‐onset mood disorder (COMD) cases. There was no difference between COMD suicide attempters and COMD non‐attempters with logistic regression models for any of the three markers. We also compared the three polymorphisms between 192 COMD cases and 192 matched healthy controls and found no significant differences between COMD and healthy controls. Our results do not support an association of the p75 NTR S205L polymorphism with risk for COMD or SA in COMD. © 2007 Wiley‐Liss, Inc.