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CHMP2B mutations are not a cause of dementia in Dutch patients with familial and sporadic frontotemporal dementia
Author(s) -
Rizzu Patrizia,
van Mil Saskia E.,
Anar Burcu,
Rosso Sonia M.,
Kaat Laura Donker,
Heutink Peter,
van Swieten John C.
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30410
Subject(s) - frontotemporal dementia , dementia , medicine , mutation , disease , genetics , danish , gene , biology , linguistics , philosophy
Mutations in the CHMP2B gene have been recently identified in a large Danish pedigree with autosomal dominant frontotemporal dementia (FTD) linked to chromosome 3 (FTD3). We report the frequency of CHMP2B mutations in 162 FTD patients recruited from a large population‐based study of FTD carried out in The Netherlands. Our results suggest that mutations in CHMP2B are a rare cause of FTD as compared to MAPT mutations. © 2006 Wiley‐Liss, Inc.