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Family‐based association study between brain‐derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
Author(s) -
Xu Xiaohui,
Mill Jonathan,
Zhou Kaixin,
Brookes Keeley,
Chen ChihKen,
Asherson Philip
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30406
Subject(s) - proband , brain derived neurotrophic factor , haplotype , allele , attention deficit hyperactivity disorder , neurotrophic factors , polymorphism (computer science) , psychology , genetics , medicine , oncology , biology , psychiatry , gene , mutation , receptor
Brain‐derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention‐deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: χ 2 = 6.78, P = 0.009) and the two samples pooled together (TDT: χ 2 = 7.24, P = 0.007). No association was found between the Val66Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Val66 allele and the 270T allele in the Taiwanese samples (TDT: χ 2 = 4.57, P = 0.032) and the pooled sample set (TDT: χ 2 = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD. © 2006 Wiley‐Liss, Inc.