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Association study of seven polymorphisms in four serotonin receptor genes on suicide victims
Author(s) -
Videtic Alja,
Pungercic Galina,
Pajnic Irena Zupanic,
Zupanc Tomaz,
Balazic Joze,
Tomori Martina,
Komel Radovan
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30390
Subject(s) - genotype , polymorphism (computer science) , depression (economics) , receptor , 5 ht receptor , poison control , genetics , serotonin , biology , psychology , gene , medicine , medical emergency , economics , macroeconomics
A number of molecular genetic studies have investigated if serotonin (5‐HT) receptor subtypes are involved in the pathogenesis of depression, suicidal behavior, aggression, and impulsive behavior. Existence of many receptor subtypes for a single transmitter permits a great diversity of signaling raising the possibility that they may serve as genetic markers for suicidal behavior. Most previous studies of suicide have analyzed polymorphisms of the receptors 5‐HT 1A , 5‐HT 1B , 5‐HT 2A , fewer have examined 5‐HT 1F . We report a study of possible association between the polymorphisms in the 5‐HT receptor genes (1A, 1B, 1F, and 2A) and suicidal behavior on a sample of 226 suicide victims and 225 healthy control subjects. No significant differences in genotype frequency distributions between the suicide victims and healthy control subjects were observed for four polymorphisms; three were not polymorphic. A single polymorphism, C‐1420T in gene 5‐HT 2A , showed a slight association with suicide (χ 2 = 4.94, df = 2, P = 0.067), but the correlation was not statistically significant. None of the tested genetic variants of serotonin receptors appears to be associated with suicidal behavior in the Slovenian population which has a relatively high suicide rate. © 2006 Wiley‐Liss, Inc.