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Linkage of schizophrenia with chromosome 1q32 in Korean multiplex families'
Author(s) -
Jang Yong Lee,
Kim Jong Won,
Lee YuSang,
Park Dong Yeon,
Cho EunYoung,
Jeun Hyun Ok,
Lee Dongsoo,
Hong Kyung Sue
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30389
Subject(s) - linkage (software) , genetic linkage , genetics , microsatellite , multiplex , chromosome , biology , schizophrenia (object oriented programming) , population , psychosis , gene , medicine , allele , psychiatry , environmental health
Chromosome 1q contains a few loci for which modest evidence of linkage with schizophrenia has been reported in several independent studies. However, markers showing the peak linkage signal are dispersed over a large chromosomal region. In addition, inconsistent findings have been generated from different populations or different subgroups of the same populations. The purpose of the current study is to determine whether those loci are linked to schizophrenia in the Korean population. We investigated 46 Korean multiplex schizophrenia families, initially using 11 microsatellite markers spanning around 91 cM region of 1p22∼42. In a non‐parametric linkage analysis, D1S249 located on 1q32.1 showed statistical evidence suggestive of linkage. At the second stage analysis for narrowing down the region, four additional nearby markers were genotyped. In the single point analysis, we found another suggestive linkage signal at D1S2891. The highest NPL score of 2.67 ( P = 0.0039) was obtained in the multi‐point analysis. This study provides supportive evidence for linkage of chromosome 1q32 with schizophrenia. © 2006 Wiley‐Liss, Inc.