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Further evidence of MAO‐A gene variants associated with bipolar disorder
Author(s) -
Müller Daniel J.,
Serretti Alessandro,
Sicard Tricia,
Tharmalingam Subi,
King Nicole,
Artioli Paola,
Mandelli Laura,
Lorenzi Cristina,
Kennedy James L.
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30380
Subject(s) - bipolar disorder , haplotype , allele , medicine , genetics , psychiatry , gene , biology , cognition
The aim of this study was to investigate MAOA gene variants in bipolar disorder by using a family‐based association approach. The first sample included 331 nuclear families from Western and Central Canada with at least 1 offspring affected with bipolar disorder comprising a total of 1,044 individuals. All subjects were genotyped for MAOA–941T > G and −uVNTR gene variants using PCR techniques. Haplotype TDT was statistically significant (LRS = 12.17; df = 3; P = 0.0068; permutation global significance = 0.00098), with the T‐4 haplotype significantly associated with bipolar disorder (OR = 1.63, 95% CI = 1.11–2.37). Single marker analysis evidenced a borderline association for MAOA–941T > G ( P = 0.04), but not for the uVNTR. Pooling the Canadian sample with a second previously reported Italian sample genotyped for the uVNTR variant, negative results were obtained as well. No different results were detected when analyzing female subjects separately. In conclusion, our family‐based association study gives mild but further support of the involvement of MAOA variants in bipolar disorder. © 2006 Wiley‐Liss, Inc.