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Heritability and clinical features of multigenerational families with obsessive‐compulsive disorder and hoarding
Author(s) -
Mathews Carol A.,
Nievergelt Caroline M.,
Azzam Amin,
Garrido Helena,
Chavira Denise A.,
Wessel Jennifer,
Bagnarello Monica,
Reus Victor I.,
Schork Nicholas J.
Publication year - 2007
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30370
Subject(s) - hoarding (animal behavior) , heritability , hoarding disorder , proband , linkage (software) , psychology , genome wide association study , compulsive behavior , clinical psychology , genetics , medicine , biology , single nucleotide polymorphism , genotype , feeding behavior , gene , mutation
To date, only one complete genome screen for obsessive‐compulsive disorder (OCD) has been published. That study identified a region of suggestive linkage (maximum lod score of 2.25) with a relatively small sample size (N = 56; 27 with OCD). Additional complete genome screens are needed to confirm this finding and identify other regions of linkage. We present the clinical characteristics and power to detect linkage of 11 multigenerational families with OCD and hoarding (N = 92; 44 with OCD), as well as heritability estimates for several quantitative traits. Families with at least two individuals with OCD were identified through probands with childhood‐onset OCD. Expected lod scores were calculated for simulated genetic marker data under an additive and two dominant models assuming a dense SNP marker map. All affected individuals had an early age of onset (18 or younger). Hoarding was present in 46% of subjects. Obsessive‐compulsive symptoms and hoarding were highly heritable. The maximum mean expected lod score was 3.31 for OCD and 1.39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding. © 2007 Wiley‐Liss, Inc.