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No association between ADRA2A polymorphisms and schizophrenia
Author(s) -
Clark D.A.,
Mata I.,
Kerwin R.W.,
Munro J.,
Arranz M.J.
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30355
Subject(s) - single nucleotide polymorphism , schizophrenia (object oriented programming) , schizoaffective disorder , genetic association , genetics , biology , snp , gene , psychosis , genotype , medicine , psychiatry
There is evidence to suggest that the α 2A ‐adrenergic receptor may be involved in schizophrenia. With attention directed at the upstream regulatory region of the gene which codes for this receptor (ADRA2A), we proposed that single nucleotide polymorphisms (SNPs) within this region influences susceptibility to schizophrenia by altering the expression of this receptor. We opted to test for an influence on susceptibility by association study using 112 schizophrenic/schizoaffective disorder patients and 159 controls. The region of interest was screened for SNPs using a combination of bioinformatic searches and sequencing. A total of nine SNPs were discovered, of which four (−5972‐G/A, −2211‐A/T, −1291‐C/G and −261‐G/A) were genotyped in the entire clinical sample. No associations were evident, suggesting no influence for these SNPs in susceptibility to schizophrenia. © 2006 Wiley‐Liss, Inc.