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Association analysis of δ‐opioid receptor gene polymorphisms in methamphetamine dependence/psychosis
Author(s) -
Kobayashi Hideaki,
Hata Harumi,
Ujike Hiroshi,
Harano Mutsuo,
Inada Toshiya,
Komiyama Tokutaro,
Yamada Mitsuhiko,
Sekine Yoshimoto,
Iwata Nakao,
Iyo Masaomi,
Ozaki Norio,
Itokawa Masanari,
Naka Maki,
Ide Soichiro,
Ikeda Kazutaka,
Numachi Yohtaro,
Sora Ichiro
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30337
Subject(s) - single nucleotide polymorphism , linkage disequilibrium , exon , psychosis , genetics , snp , biology , genotype , methamphetamine , genetic association , gene , medicine , psychiatry , pharmacology
The role of the δ‐opioid receptor ( OPRD1 ) in methamphetamine (MAP) addiction was investigated using association analysis between OPRD1 gene polymorphisms and MAP dependence/psychosis. DNA samples from Japanese patients with MAP dependence/psychosis were analyzed to find polymorphisms in OPRD1 gene exons and exon–intron boundaries. One novel single nucleotide polymorphism (SNP) in intron 1 and two SNPs in exon 3 were identified. The two SNPs in exon 3 were in linkage disequilibrium. No significant difference was observed in either genotypic or allelic frequencies of these SNPs between controls (n = 260) and MAP dependent/psychotic patients (n = 170). Global analyses using the three SNPs and subcategory analyses on clinical parameters also showed no significant differences. These results suggest that the OPRD1 gene variants may not be a factor in vulnerability to MAP dependence/psychosis. © 2006 Wiley‐Liss, Inc.