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Contribution of 5‐HT2A receptor gene ‐1438A>G polymorphism to outcome of attention‐deficit/hyperactivity disorder in adolescents
Author(s) -
Li Jun,
Kang Chuanyuan,
Wang Yufeng,
Zhou Rulun,
Wang Bing,
Guan Lili,
Yang Li,
Faraone Stephen V.
Publication year - 2006
Publication title -
american journal of medical genetics part b: neuropsychiatric genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.393
H-Index - 126
eISSN - 1552-485X
pISSN - 1552-4841
DOI - 10.1002/ajmg.b.30320
Subject(s) - attention deficit hyperactivity disorder , phenotype , polymorphism (computer science) , serotonin , psychology , neurotransmitter systems , gene , genetics , medicine , receptor , psychiatry , genotype , biology
Abstract Attention‐deficit/hyperactivity disorder (ADHD) typically emerges before 7 years of age and may persist into adolescence or adulthood. The adolescent outcome can be classified into four types, including non‐remission, syndromatic remission, symptomatic remission, and functional remission. Genetic factors are believed to contribute to symptom stability and change across development, so adolescent outcome may be a sub‐phenotype for molecular genetic studies of ADHD. Serotonin system genes are prime candidates for this sub‐phenotype, since the development of this neurotransmitter system parallels the course of ADHD. The current study examined the association between adolescent outcome in ADHD and serotonin system genes, including the ‐1438A>G polymorphism of the serotonin 2A receptor gene (HTR2A) and the ‐759C>T polymorphism of the serotonin 2C receptor gene (HTR2C). The ‐1438A>G polymorphism was found to be related to remission in ADHD, especially functional remission ( P = 0.029). Due to potential phenotypic and etiologic heterogeneity in ADHD, the results of this study must be replicated in additional samples before they can be generalized to other populations. © 2006 Wiley‐Liss, Inc.